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Mind the Ga(b)p! – A novel hepatic gatekeeper at the switch point of metabolic homeostasis and diabetic late complications controlled by reactive metabolites

K Niopek, M Berriel Diaz, P Nawroth, S Herzig · Diabetologie und Stoffwechsel · 2015 · Heft 04

Dokument
1145081
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
K Niopek, M Berriel Diaz, P Nawroth, S Herzig
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549568

Zusammenfassung

Introduction: Type 1 and type 2 diabetes and diabetic late complications are often associated with states of chronic inflammation characterized by increased amounts of circulating reactive metabolites and proinflammatory cytokines, such as Tumor necrosis factor-alpha (TNF-α), which affect metabolic tissues by impairing physiologic hormone and nutrient signaling. So far, the molecular response to cytokine signaling in metabolic tissues, including the liver, is only marginally understood. Results: In a screen to identify transcriptional regulators responsive to inflammatory signaling we found that the activity of…

Schlagworte

Cytokines Cytokine Affect Work Tumor Diabetologie und Stoffwechsel