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Differential effects of C1q/tumor necrosis factor-related proteins on cardiomyocyte glucose metabolism

L Li, D Stumpp, B Siegler, B Niemann, S Rohrbach · Diabetologie und Stoffwechsel · 2015 · Heft 04

Dokument
1145084
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
L Li, D Stumpp, B Siegler, B Niemann, S Rohrbach
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549598

Zusammenfassung

Background: The adipose tissue-derived cytokine adiponectin plays a major role in glucose metabolism. A family of adiponectin paralogs, designated as C1q/tumor necrosis factor-alpha-related proteins (CTRPs) and comprising 15 members, has recently been discovered. While independent CTRP receptors have not been identified so far, the adiponectin receptor AdipoR1 has been suggested to be involved in CTRP signaling. However, there are no data on CTRP effects on glucose metabolism in cardiomyocytes available so far. Results: Glucose uptake and translocation of the insulin-dependent glucose transporter GLUT-4 was sign…

Schlagworte

Adiponectin Tumor Cytokine Adenine Obesity Diabetologie und Stoffwechsel