Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet
M Penke, PS Larsen, S Schuster, T Gorski, A Meusel, S Richter, SG Vienberg, JT Treebak, W Kiess, A Garten · Diabetologie und Stoffwechsel · 2015 · Heft 04
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Zusammenfassung
Introduction: Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme for NAD salvage and the abundance of Nampt has been shown to be altered in non-alcoholic fatty liver disease (NAFLD) which is strongly associated with Type 2 Diabetes and the metabolic syndrome. It is, however, unknown how hepatic Nampt is regulated in response to accumulation of lipids in the liver of mice fed a high-fat diet (HFD). Methods: C57BL/6 mice were fed a control diet (n = 12) or a HFD containing 60% of total energy from fat (n = 12) for 11 weeks. Glucose and insulin tolerance tests were performed. Hepatic lipids…
