Novel insights in cross-generational diabetic programming an established in vivo-model

Hypothesis: Maternal diabetes peri-gestational is clearly associated with increased risk for insulin resistance and type 2 diabetes in the next generation. However, since maternal risk factors are still controversy discussed we specifically designed this study to focus on the effects of gestational weight gain (GWG) respectively maternal fasting blood glucose (FBG) concentrations during pregnancy and its outcomes on their offspring. Methods: We recently developed an in vivo model usable to analyze cross-generational mechanisms of diabetic programming. Therefore, female age-matched diabetic mice (DM; n= 6) and th…