Role of HOXC9 and HOXC10 in human obesity
JE Brune, M Kern, T Lohmann, MR Schön, A Dietrich, M Stumvoll, M Blüher, N Klöting · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aim: Hox-Genes code for transcription factors known for their role in embryonic patterning. Furthermore, an impact on body fat distribution is under discussion. Own unpublished data revealed high differences in expression levels of HoxC9 and HoxC10 between subcutaneous and visceral fat in mice. Our aim was to examine the relevance of these two genes in obesity in man. Subjects and methods: mRNA expression levels of HOXC9 and HOXC10 were measured by qRT-PCR in paired samples of human subcutaneous and visceral adipose tissue (n = 636) as well as in adipocytes and stromavascular fraction (SVF) which were isolated f…
