Interferon-free regimens overcome the effect of portal hypertension on virologic response
M Mandorfer, K Kozbial, C Freissmuth, P Schwabl, AF Stättermayer, T Reiberger, S Beinhardt, R Schwarzer, M Trauner, A Ferlitsch, H Hofer, M Peck-Radosavljevic, P Ferenci · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Clinically significant portal hypertension (CSPH) is the strongest predictor of virologic response to pegylated interferon (IFN)/ribavirin in patients with chronic hepatitis C (CHC) and cirrhosis. Aim: To investigate the impact of portal pressure assessed by hepatic venous pressure gradient (HVPG) measurement on on-treatment response and viral kinetics in patients treated with IFN-free regimens outside of clinical trials. Methods: Fifty-six patients with CHC and cirrhosis who underwent HVPG measurement before starting an IFN-free therapy were retrospectively studied. CSPH and pronounced portal hypert…
