Impact of SNP rs2187668 in HLA-DQA1 on clinical presentation and treatment response in patients with type-1 autoimmune hepatitis
AF Stättermayer, M Eder, S Beinhardt, K Kozbial, C Freissmuth, F Wrba, M Trauner, P Ferenci, H Hofer · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background/aim: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with limited etiopathogenetic understanding. Recently, a genome-wide association study (GWAS) identified a single nucleotide polymorphism (SNP, rs2187668) in the HLA-DQA1 gene, which is strongly associated with AIH type-1. We therefore evaluated the impact of this SNP on clinical presentation and treatment response in patients with AIH. Methods: One-hundred and six patients with type-1 AIH (female: 82 [77.4%], mean age: 43.1 [CI95%: 39.7 – 46.5] years), who reached a probable or definite score according to the simplified or revise…
