CareLit Fachartikel
Absence of BSEP/ABCB11 protects from cholestatic liver and bile duct injury in a mouse model of sclerosing Cholangitis
CD Fuchs, G Paumgartner, A Wahlström, T Stojakovic, H Marschall, M Trauner · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Dokument
1145240
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Jahr
2015
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Zusammenfassung
Cholestasis leads to liver injury reflected by disruption of hepatocellular integrity, inflammation and fibrosis. Bile salt export pump (BSEP/ABCB11) is the main canalicular BA transporter and therefore rate limiting step for hepatobiliary BA secretion. Here we investigate the role of ABCB11 in development of cholestatic liver and bile duct injury in a model of sclerosing cholangitis. WT and ABCB11KO mice were subjected to common bile duct ligation (CBDL) and DDC feeding as models for acute and chronic cholestasis, respectively. RNA profiling was performed by RT-PCR. BA transporter expression was assessed at pro…
Schlagworte
Cholestasis
Cholangitis
Biochemistry
Cholesterol
After
Zeitschrift für Gastroenterologie
