Cardiovascular complications of cancer treatment: update CACOCA trial

Rationale. Oncological treatment, applying chemotherapy or new targeted drugs has already shown to induce cardiotoxicity. Present knowledge is primarily based on patients, who were treated in prospective clinical trials and is focused on acute toxicities. In contrast, there is a lack of data concerning the long-term cardiotoxic effects of systemic cancer therapies. The present trial aims to prove the risk and the consequences of long-term cardiotoxicity experienced after different cancer treatments in an unselected cohort of patients. Methods. In this prospective, non-interventional, multicenter trial 1000 patie…