Regional differences in Cl- conductance in human nasal epithelial primary cells (hNEpC) of patients with chronic rhinosinusitis

Chronic rhinosinusitis (CRS) is considered as a common disease with symptoms such as nasal obstruction and discharge. CRS also is a prevalent feature of cystic fibrosis and other lung diseases (e.g. primary ciliary dyskinesia). The underlying pathophysiologic mechanisms of CRS have not yet been clearly identified. The purpose of this study is to functionally characterise epithelial chloride conductance in two distinct nasal regions in patients with CRS. hNEpC were freshly isolated from nasal tissue close to processus uncinatus (hNEpC-PU) and paranasal sinus (ethmoid bone, hNEpC-PS) from patients undergoing polyp…