CareLit Fachartikel
Mutational DNA profile in non-atypical endometriomas using Next-generation-sequencing
EP Samartzis, M Rechsteiner, A Noske, N Samartzis, D Fink, P Imesch · Geburtshilfe und Frauenheilkunde · 2015 · Heft 07
Dokument
1145442
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Endometriosis is a common gynecologic disorder, affecting at least 6 – 10% of reproductive-aged women. Endometriotic implants are observed all over the pelvis but the endometriosis-associated cancers typically arise in endometriomas. This observations rise up the question whether the special ovarian cyst environment, especially oxidative stress caused by free „catalytic“ iron, induces cancer driver gene mutations in endometriotic implants that may lead to carcinogenic transformation in these cysts. Material and Methods: The study was approved by the cantonal ethics committee. Formalin-fixed and par…
Schlagworte
Allele
Population
Workflow
Pelvis
Aged
Lead
Tumor
Geburtshilfe und Frauenheilkunde
