Distinct CD4+ T cell subset composition with higher Th17/Treg ratio in peripheral blood and hepatic tissue of patients with NAFLD, NASH and healthy controls
M Rau, A Schilling, J Meertens, I Hering, T Kudlich, C Jurowich, N Beyersdorf, A Geier · Zeitschrift für Gastroenterologie · 2015 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising in the last decades and non-alcoholic fatty liver (NAFL) as well as non-alcoholic steatohepatitis (NASH) are now endemic in Western countries. The current hypothesis about the pathogenesis is a two hit theory, i.e. first steatosis due to e.g. metabolic syndrome and then inflammation of the fatty liver due to bacterial translocation from the gut. Thus, 5 to 20% of NAFL patients progress to NASH. It is still not well understood why some patients develop NASH and others remain with NAFL. Higher frequencies of Th17 cells were observed…
