Non-alcoholic fatty liver disease (NAFLD) is associated with a distinct fecal microbiome signature – a case control study
C Schulz, M Lerch, L Lahti, J Kühn, K Schütte, F Weiss, H Völzke, S Baumeister, S Fuentes, G Fluhr, W de Vos, J Mayerle · Zeitschrift für Gastroenterologie · 2015 · Heft 08
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Zusammenfassung
Background: Nonalcoholic fatty liver disease is now being recognized as the most common liver disorder worldwide. The majority of NAFLD patients are characterized by mere liver steatosis but up to one third progresses to non-alcoholic steatohepatitis (NASH). The underlying pathophysiology is poorly understood but changes in the gut microbiome have been suggested to be involved. Design: Using a case control design we recruited 84 subjects with liver steatosis and 83 controls from the population-based Study of Health in Pommerania. Subjects with diabetes mellitus, BMI > 25 kg/m2, immoderate alcohol intake or galls…
