Evaluation of Diffusion-weighted magnetic resonance imaging for therapy response in pancreatic cancer in mouse models
M Trajkovic-Arsic, I Heid, K Steiger, A Gupta, A Fingerle, C Wörner, N Teichmann, P Wenzel, A Herner, A Steingötter, A Beer, M Schweiger, M Settles, B Haller, I Esposito, E Rummeny, R Schmid, R Braren, J Siveke · Zeitschrift für Gastroenterologie · 2015 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: New therapeutic regimens for otherwise lethal pancreatic ductal adenocarcinoma (PDAC) are rapidly emerging. Thus, imaging-based biomarkers that would allow early assessment of therapy response would be of great need. Methods: In a preclinical therapy approach, we used a a Ptf1awt/cre;Kraswt/LSL-KrasG12D;p53fl/fl (CKP furtheron) genetically engineered mouse model (GEMM) that develops moderately differentiated PDAC with strong stromal reaction and thus faithfully recapitulates characteristics of locally advanced human PDAC. Animals were subjected to 2 different therapy regimens, gemcitabine and refam…
