Hypothesis-driven “HDAC-autophagy” gene cluster to identify HDAC inhibitor treatment responsive tumor entities

Histone deacetylases (HDAC) have been identified as promising targets in the treatment of multiple types of cancer, including neuroblastoma and medulloblastoma. HDACs play important roles not only in histone modification resulting in chromatin remodeling and gene expression changes, but they also play direct roles in cellular processes including autophagy, apoptosis, cell mobility, and metabolism. Two histone deacetylases recently identified as promising targets in neuroblastoma are HDAC8 and HDAC10. High levels of HDAC8 expression are correlated with stage 4 disease, and high levels of HDAC10 are associated wit…