Is PTEN subject to mRNA editing in glioblastoma xenografts?

In the context of molecular characterization of glioblastoma models, comparative mutation analysis of primary tumors, cell lines and heterotopic mouse xenografts was performed. One of the most frequently affected genes in glioblastoma is PTEN, normally considered as tumor suppressor gene, but, depending on the mutation, can also show other effects. PTEN mutation analysis was initially performed on cDNA. When the PTEN sequence of xenograft derived cDNA was compared to that of the corresponding patient derived primary cell line, it was observable that the xenograft derived sequences showed several silent mutations…