Beneficial effects of IL-1 cytokine inactivation and the role of the serine/threonine kinase MK-2 in hepatic steatosis in a murine obesity model
J Wohlfahrt, A Fettelschoss, T Kündig, H Hermanns, B Müllhaupt, J Schmitt, A Geier · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background and Aims: Although non-alcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease worldwide, its pathogenesis is yet poorly understood. Recent studies show that the pro-inflammatory cytokines IL-1αand IL-1β play a crucial role in disease development. Their recognition by cells does not only result in transcriptional regulation of many IL-1 target genes, but also negatively affects cell surface expression of the IL-6 signal transducer gp130 in an MK-2 (mitogen-activated protein kinase-activated protein kinase 2)-dependent mechanism. Therefore the cells might become l…
