Association of immune cell infiltration and tumor suppression in hepatocellular carcinoma

Background: Different inflammatory states, e.g. chronic hepatitis B or C virus infection, have been shown to contribute to the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms and regulation of immune cell infiltration during hepatocarcinogenesis are still poorly understood. Recently, we applied an integrative genomic and transcriptomic approach in HCC which revealed that loss of chromosome 8 p is associated with poor prognosis. In addition, we showed that the two chromosome 8 p genes SORBS3 and SH2D4A are functional tumor suppressor genes in vitro and in vivo. In this study, we a…