High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis
F Finkelmeier, O Canli, A Tal, T Pleli, J Trojan, M Schmidt, A Piiper, B Kronenberger, S Zeuzem, FR Greten, O Waidmann · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Aim: Immunotherapy in cancer is a recent and very promising approach, namely the inhibition of the PD/PD-L1 axis. New treatment strategies in HCC are desperately wanted. Here we aimed to investigate the prognostic value of a soluble form of PD-L1 in hepatocellular carcinoma patients. Methods: HCC patients were prospectively recruited and sPD-L1 (serum soluble programmed death-ligand 1) levels were determined. sPD-L1 levels were compared to stages of cirrhosis and HCC stages. The association of the sPD-L1 levels and overall survival (OS) was assessed in uni- and multivariate Cox regression models. Results: 215 pa…
