CareLit Fachartikel
The HLA-DPA1 rs3077 TT polymorphism is associated with spontaneous resolution of hepatitis B virus (HBV) infections in Caucasians
E Koukoulioti, J Fischer, S Boehm, T Berg, F van Bömmel · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1145740
CareLit-ID
Jahr
2015
Publikation
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nein
Metadaten
DOI
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Zusammenfassung
Background: Human leukocyte antigens (HLA) play an important role in the regulation of immune response against infectious organisms, including HBV. Single nucleotide polymorphisms (SNPs) within the HLA-DP locus were recently found to be associated with HBV infection and viral clearance in Asian populations, but little is known about implications of these variants for the course of HBV infection in Caucasians. We aimed to investigate the impact of HLA-DPA1 rs3077 and HLA-DPB1 rs9277534 polymorphisms on the likelihood of spontaneous HBsAg clearance in a mainly European population. Methods: 435 chronic hepatitis B…
Schlagworte
Association
Population
Hepatitis
Antigens
Blood
Zeitschrift für Gastroenterologie
