Priming with respiratory bacteria alters the airway epithelial response to subsequent viral infection
C Bellinghausen, F Gulraiz, EFM Wouters, G Rohde, FRM Stassen · Pneumologie · 2016 · Heft 02
Bibliografische Angaben
Zusammenfassung
Background: The lungs of patients suffering from chronic respiratory diseases, such as chronic obstructive pulmonary disease, asthma or cystic fibrosis, are frequently colonized with potentially pathogenic bacteria. Additionally, these patients are particularly susceptible to viral infections, which can lead to acute exacerbation of the disease. In this study, we investigated if exposure to the most common respiratory bacterial pathogens alters the response of lung epithelial cells towards subsequent viral infection. Methods: We exposed bronchial epithelial cells (BEAS-2B and primary bronchial epithelial cells)…