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MicroRNA-155 modulates P2R-signaling and Th2-priming of dendritic cells during allergic airway inflammation in mice

A Zech, K Ayata · Pneumologie · 2016 · Heft 02

Dokument
1145839
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Zech, K Ayata
Ausgabe
Heft 02 / 2016
Seiten
–
Erschienen: 2016-02-09 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0036-1572128

Zusammenfassung

Background: Dendritic cells (DCs) are the professional antigen presenting cells (APCs) in the lungs. They are known to be key players in the induction and maintenance of allergic asthma by cross linking innate and adaptive immune responses. MicroRNAs (miRNAs) are known to influence cell fate and function by translational suppression or induction of messenger-RNA (mRNA) degradation. MiR-155 has been shown to be a crucial regulator of the immune system. However, its function in the pathogenesis of allergic airway inflammation (AAI) is not completely elucidated yet. Methods: Wildtype (WT) and miR-155 deficient (miR…

Schlagworte

Dendritic Cells Antigen-Presenting Cells Adoptive Transfer Chemotaxis Asthma Pneumologie