CareLit Fachartikel
Identification of trafficking proteins involved in adiponectin secretion
M Rödiger, MW Werno, D Hesse, A Schürmann · Diabetologie und Stoffwechsel · 2016 · Heft 04
Dokument
1145890
CareLit-ID
Jahr
2016
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Background: Adiponectin is an insulin-sensitizing hormone which is produced and secreted exclusively by adipose tissue. After synthesis and multimerization of the single 30 kDa polypeptide within the endoplasmic reticulum, the adipokine proceeds through compartments of the Golgi apparatus and is subsequently released into the bloodstream. The ubiquitously expressed GTPase ARFRP1 (ADP-ribosylation factor-related protein 1) controls a scaffolding machinery at the trans-Golgi that is supposed to target intracellular vesicles to their correct destination. We therefore aim to elucidate the role of ARFRP1 on adipocyte…
Schlagworte
Adiponectin
Adipocytes
Adipokine
ADP-Ribosylation
Blood Glucose
Adipokines
Blood
After
Diabetologie und Stoffwechsel
