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Identification of novel diabetes-related loci in a backcross of obese NZO with lean C3 H mice

D Altenhofen, T Schallschmidt, S Lebek, M Damen, Y Schulte, A Chadt, H Al-Hasani · Diabetologie und Stoffwechsel · 2016 · Heft 04

Dokument
1145894
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
D Altenhofen, T Schallschmidt, S Lebek, M Damen, Y Schulte, A Chadt, H Al-Hasani
Ausgabe
Heft 04 / 2016
Seiten
–
Erschienen: 2016-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1580808

Zusammenfassung

Background: The identification of novel diabetes risk genes is an essential field for prevention and treatment of the disease. Mouse models represent useful tools to investigate diabetes-genetics factors associated to respective cellular function. In this project, a backcross between diabetes-susceptible New Zealand Obese (NZO) and lean C3HeB/FeJ mice was performed in order to identify potential new diabetes-inducing or -protective candidate genes. Methods: The resulting N2 population from a backcross of NZO-C3HeB/FeJ mice was raised on a high-fat diet (45% fat/cal.) Diabetes-phenotypic traits as body weight, bo…

Schlagworte

Diet Blood Glucose Population Allele Blood Diabetologie und Stoffwechsel