How an altered adiponectin level during early diabetic pregnancy influences embryonic lipid metabolism

Aim: An experimentally-induced maternal diabetes mellitus leads to a strongly increased level of intracellular lipid droplets in early embryos, correlating with increased adiponectin levels in the uterine environment (Schindler et al. Endocrinology 2013 and 2014). Adiponectin maintains energy homeostasis and may affect early embryo lipid metabolism. The object of current study was to find a potential link between adiponectin and the disturbed embryonic lipid metabolism in a diabetic pregnancy. Methods: The effect of adiponectin was investigated in embryos from two experimental models, in i) in vivo blastocysts f…