Hijacking the general transcription machinery by sequence specific transcription factors going awry
M Seoane, J Strauss, AC Puller, PI Vazquez, M Noshiravani, S Feldhaus, M Alawi, MG Kaul, JM Brandner, J Du, J Thomale, PJ Wild, M Zimmermann, T Sternsdorf, P Nollau, U Schumacher, DE Fisher, MA Horstmannm · Klinische Pädiatrie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: The MiT family of transcription factors comprises four closely related members, MiTF, TFE3, TFEB and TFEC. All members of this family share a common structure, consisting of the helix-loop-helix leucine zipper dimerization motif, the transactivation domain and a DNA-binding domain that recognizes the consensus sequences (CA[T/C]GTG) called E-boxes. Due to the high homology between all MiT family members the unique function of each family member may therefore be dependent on its expression pattern and the different isoforms expressed in each tissue. Although their dysregulation by amplification, mis…
