TARGIT E(lderly) – Prospective phase II study of Intraoperative Radiotherapy (IORT) in elderly patients with small breast cancer

Purpose: To further investigate the efficacy of IORT within elderly low risk patients with breast cancer (≥70y, cT1cN0cM0, invasive-ductal histology) which is followed by whole breast radiotherapy (WBRT) only when risk factors are present. This prospective, multicentric single arm phase II study (NCT01299987) is based on the experimental arm of the randomized protocol of the TARGIT A study. We present the first outcome analysis from 20 German centers. Methods: 273 patients were recruited between 02/2011 – 09/2014. Forty-one were excluded from the analysis because of screening failure, drop-out or loss to follow-…