CareLit Fachartikel
The human lung lipidome mirrors histopathological phenotypes of lung tissues
LF Eggers, J Müller, V Scholz, T Goldmann, D Schwudke · Pneumologie · 2016 · Heft 07
Dokument
1146080
CareLit-ID
Jahr
2016
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Lipid metabolism is closely connected to respiratory functions. Especially, pulmonary surfactant is constantly synthesized, stored, and secreted by type II pneumocytes located in the alveoli. Disruption of this metabolism affects lung functions in a not yet well characterized manner. To gain insight into these fundamental physiological processes, we present a systematic lipidomics study of 43 human lung tissue samples from 26 lung-cancer patients. Each biopsy was split equally to perform histopathology and shotgun lipidomics. Lung samples were characterized by a tissue-specific scoring system that covered, among…
Schlagworte
Tumor
Cholesterol Esters
Association
Cholesterol
Biopsy
Pneumologie
