Identification of biomarkers predicting COPD exacerbations
M Wolff, B Hammer, S Reuter, S Bartel, S Krauss-Etschmann, H Fehrenbach · Pneumologie · 2016 · Heft 07
Bibliografische Angaben
Zusammenfassung
Introduction: COPD affects 600 million patients worldwide (WHO). The disease is mainly caused by long-term smoking of cigarettes. Symptoms include progressive airflow limitation and chronic airway inflammation. Several triggers (e.g. bacterial or viral infections) can induce acute exacerbations. These episodes of acute worsening of disease symptoms are a significant burden for both patients and health care systems. Moreover, frequent exacerbations lead to more rapid lung function decline and increased mortality. Early prediction of exacerbations could help to initiate treatment before symptoms reach a critical l…