CareLit Fachartikel
Innate immune network in asthma: studies on dendritic cell interaction with airway epithelium
K Stein, A Jenckel, U Jappe, H Heine · Pneumologie · 2016 · Heft 07
Dokument
1146082
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Background: The interaction of various types of innate and adaptive immune cells during ongoing allergic asthma is pivotal for the outcome and the resolution of the disease. Dendritic cells (DC) are key regulators of this network, however, the airway epithelium is the first entry site for airborne allergens and signals derived from these cells can affect DC function decisively. Methods: A 3D co-culture model involving the airway epithelial cell line Calu-3, cultured under air-liquid interface (ALI) conditions, and monocyte-derived DC was used to study the interaction of these cell types when challenged with airb…
Schlagworte
Allergens
Asthma
Dendritic Cells
Cytokines
Cytokine
Affect
Pneumologie
