Genetic polymorphisms in fatty liver disease in HIV positive patients receiving combined antiretroviral therapy (cART)
L Dold, C Luda, C Schwarze-Zander, C Bösecke, C Berger, HD Nischalke, RU Mohr, JC Wasmuth, CP Strassburg, JK Rockstroh, U Spengler · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Hepatic steatosis possibly occurs with any type of antiretroviral therapy (cART). Genome wide association studies have identified 7 single nucleotide polymorphisms (SNPs) predisposing to fatty liver disease in obesity. In this study, we analyzed if the risk of developing fatty liver under cART is associated to single nucleotide polymorphisms in HIV positive patients. Methods: 142 HIV positive patients under cART (median 96 months of treatment duration) were recruited into the study. Using a non-invasive method “controlled attenuation parameter” (CAP) integrated in Fibroscan, we assessed live…
