Circulating cell-free DNA is a reliable tool to detect hot spot mutations in intraductal papillary mucinous neoplasms
A Berger, D Schwerdel, I Costa, T Hackert, O Strobel, S Lam, T Barth, A Meining, B Schröppel, M Zenke, P Hermann, T Seufferlein, A Kleger · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Bibliografische Angaben
Zusammenfassung
Pancreatic ductal adenocarcinoma (PDAC) is the most common cancer type of the pancreas. The three PDAC precursor lesions are: (i) pancreatic intraepithelial neoplasia (PanIN), (ii) mucinous cystic neoplasm (MCN), and (iii) IPMN. In contrast, serous cystadenomas are strictly benign cystic neoplastic lesions and rarely require surgery. Frequently, differential diagnosis of neoplastic cysts remains cumbersome. Thus, non-invasive diagnostic stratification would be welcome. Such a test should allow both discrimination of (i) IPMN from strictly benign pancreatic cysts but also (ii) low- from high-grade IPMN. Little is…
