Bcl-3 acts as a proto-oncogene in pancreatic cancer in humans and mice
J Ai, SM Wörmann, L Song, N Diakopoulos, M Lesina, D Ruess, K Görgülü, RM Schmid, H Algül · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Despite numerous efforts to develop novel therapies, pancreatic ductal adenocarcinoma (PDAC) has remained one of the most devastating and lethal malignancies worldwide. B-cell chronic lymphatic leukemia protein 3 (Bcl-3) is an atypical member of the ankyrin repeat-containing IκB family of NF-κB inhibitors that was first identified as a candidate proto-oncogene in chronic lymphocytic leukemia. Accumulating evidence reveals that elevated Bcl-3 expression results in increased cell proliferation, cell survival and malignant potential. However, the functional role of Bcl-3 in pancreatic cancer has not b…
