Severe intracranial haemorrhage with cerebral parenchymal necrosis in fetal alloimmune thrombocytopenia – a case report

Purpose: In fetal/neonatal alloimmune thrombocytopenia (FNAIT) maternal alloantibodies destroy fetal platelets, which harbour the paternal inherited agent (in 80% HPA-1a). The frequency is approximately 1:1000, but FNAIT is supposedly highly underdiagnosed. In contrast to rhesus incompatibility, this disease may already occur in the first pregnancy. Since screening is not available, FNAIT is currently not diagnosed before the occurrence of intracranial haemorrhage that may result in lifelong disability or death. Our case report intends to emphasize the importance of FAIT, especially with respect to future option…