Mesothelial and tumor cells synergize through the SCF/c-Kit axis for IDO-driven regulatory T cell-mediated immunosuppression in ovarian cancer
K Kübler, S Riemann, TH Ayub, A Abramian, C Kaiser, MD Keyver-Paik, W Barchet, W Kuhn · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: High-grade epithelial ovarian cancer (EOC) remains a deadly disease, for which more effective therapeutics are needed. EOC appears particularly amenable to immunotherapeutic strategies and especially the inhibition of immune evasion strategies might confer substantial benefit on outcome. The goal of our analysis was to provide the rationale for future anti-cancer strategies that are able to abrogate immunosuppression. Material and methods: In 33 women diagnosed with EOC the peritumoral immune cell infiltrate was analyzed by flow cytometry; levels of stem cell factor (SCF) and cytokines/chemokines a…
