The role of the tumor suppressor microRNA-1 in ovarian cancer
MB Stope, D Hettenbach, M Paditz, K Diesing, G Klinkmann, M Burchardt, D Koensgen, A Mustea · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Even though ovarian cancer (OC) represents the most lethal cancer in gynecologic oncology, an unsatisfactory characterization of the underlying cellular mechanisms primarily prevents development of promising future approaches for diagnosis, prognosis and treatment benefit. In this study we examined the role of the tumor suppressor microRNA-1 (miR-1) in OC cells and OC tumor samples to evaluate miR-1 as a putative biomarker. Materials and methods: miR-1 levels were detected by quantitative RT-PCR applying total RNA preparations from OC cell lines and tumor samples. For in vitro modulation of miR-1 exp…
