Divergent expression of two prostaglandin E receptors (EP1 and EP3) in normal endometrium (NE) and in ectopic endometriosis lesions of ovarian origin (EC)

Background: Implantation and endometriosis are the results of intricate interactions of hormones, prostaglandins and cytokines designating tissues to adhesion, migration and apoptosis. EP1 and EP3 have been implicated in promoting these processes. Although the crucial role of prostaglandins in diverse physiological and pathological processes is known, the effects of their receptors on implantation and endometriosis remain to be elucidated. Here we investigate the expression levels of prostaglandin receptors in NE and EC. Study design: Normal endometrial tissues of 46 patients from at all phases of the menstrual…