The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner
M Wiese, N Walther, C Diederichs, F Schill, S Monecke, B Downie, D Sturm, SM Pfister, R Dressel, SA Johnsen, CM Kramm · Klinische Pädiatrie · 2016 · Heft 11
Bibliografische Angaben
Zusammenfassung
Pediatric high-grade gliomas (pedHGG) belong to the most aggressive cancers in children with poor prognosis due to a lack of efficient therapeutic strategies. To identify therapeutic targets, intensive research in adult high-grade gliomas identified dysregulated and tumor-driving signal-transduction pathways. The β-catenin/Wnt-signaling pathway holds promising potential as treatment option in adults to abrogate tumor cell invasion and acquisition of “cancer stem cell” characteristics. However, pedHGG frequently differ from their adult counterparts with respect to tumor genetics and biology and observations from…
