CareLit Fachartikel
A CD-38-Like Molecule - A Novel Prostatic Antigen and its Differential Expression in Normal Prostatic Epithelium and Prostatic Disease
G. Kramer, G. Steiner, M. Marberger · Aktuelle Urologie · 1996 · Heft S 1 · S. 69-71
Dokument
1159535
CareLit-ID
Jahr
1996
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Summary: This study describes for the first time that all normal prostatic epithelial cells (PEC) intensely react with two monoclonal antibodies directed against distinct epitopes of CD38. Direct comparison of prostatic and lymphatic CD38 using Western blotting revealed identical bands at approximately 45 kD, indicating that the molecules recognized were identical. Immunogold electron microscopy demonstrated anti-CD38 reactivity on the cystoplasmic membrane and within the secretory vacuoles. Double labeling with anti-cytokeratin antibodies confirmed that basal and secretory normal PEC intensely react with anti-C…
Schlagworte
Benign prostatic hyperplasia
Prostate cancer
CD38
Prostatic antigen
Antibodies
Calcium
Tumor
Aktuelle Urologie
