Identification of multiple HSP60 epitopes in JIA and other autoimmune diseases: A promising avenue for antigen-specific immunotherapy
SSM Kamphuis, W de Jager, G Teklenburg, E Elst, G Gordon, M Massa, A Martini, GT Rijkers, NM Wulffraat, W Kuis, ABJ Prakken, S Albani · Aktuelle Rheumatologie · 2003 · Heft 11
Bibliografische Angaben
Zusammenfassung
Aim of study: Immune recognition of Heat Shock Protein 60 (HSP60) plays a role in the regulation of experimental animal models, and in human Autoimmune Diseases (AID). To determine targets for antigen-specific immunotherapy in JIA, we needed to identify HSP60 epitopes recognised by a majority of patients. Methods: With the use of a matrix-based computer algorithm predicting potential pan-DR binding sites on a given protein sequence, 4 peptides originating from human HSP60 and 4 homologous microbial peptides were identified and tested for epitope specific T cell recognition in 66 JIA patients, 25 patients with ot…
