Clonotypic archetype of the T cell repertoire in peripheral blood and synovial fluid of patients with juvenile idiopathic arthritis?

Introduction: Juvenile Idiopathic Arthritis (JIA) is characterized by chronic inflammation, synovial cell proliferation and progressive joint damage. T cells have been demonstrated to play a key role both in induction and in maintenance of chronic inflammation in Juvenile Idiopathic Arthritis (JIA). Previous studies have demonstrated discrepant results regarding the significance of T cell clonality. Objective and Methods: To investigate the T cell repertoire of the T cell receptor (TCR) in paired samples from peripheral blood and synovial fluid (SF) of patients with JIA. Oligoclonality was analysed on the base o…