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Improved Power and Resolution of QTL Mapping for Cholesterol Gallstone Susceptibility Loci Based on Combined Analysis of Two Independent Crosses

H Wittenburg, R Li, MA Lyons, MC Carey, J Mössner, GA Churchill, B Paigen · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1161678
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
H Wittenburg, R Li, MA Lyons, MC Carey, J Mössner, GA Churchill, B Paigen
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816089

Zusammenfassung

To date, employing quantitative trait locus (QTL) mapping, we have identified 16 loci that harbor cholesterol gallstone (GS) susceptibility genes (Lith loci) in inbred mice. We previously reported QTL mapping in two separate crosses of gallstone-susceptible PERA/Ei mice with each of the resistant strains I/LnJ and DBA/2J. Here, we re-analyzed the combined data based on a new binary allelic model. After consumption of a lithogenic diet, F2 offspring of PERA x I/Ln and PERA x DBA/2 crosses were phenotyped for GS weight and a scoring system for cholelithiasis. Progeny were genotyped using PCR amplification of micro…

Schlagworte

QTL mapping cholesterol gallstones inbred mice Cholesterol Cholelithiasis Alleles Diet After Zeitschrift für Gastroenterologie