Expression of suppressor of cytokine signaling-3 protein in chronic hepatitis C virus infected liver tissue
N Bektas, A zur Hausen, M Knöß, A Weber, HU Kasper, K Breuhahn, P Schirmacher, HP Dienes, H Zentgraf, CT Bock · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Bibliografische Angaben
Zusammenfassung
Aims: Hepatitis C virus (HCV) infection leads to activation of cellular and humoral immune response which is mediated by cytokines causing liver cell injury. Immune and inflammatory response are controlled by multiple cytokines, including interleukins and interferons (IFN). Suppressors of cytokine signaling (SOCS) proteins are known to be potent inhibitors of cytokine signaling via the JAK/STAT pathway. SOCS3 was reported to inhibit IFN-mediated antiviral (IFN-resistance) and antiproliferative activity which may lead to severe liver disease. Therefore, we analyzed SOCS-3 expression in chronic HCV-hepatitis by im…
