CareLit Fachartikel
Chromium pretreated rats fail to develop diabetes-like symptoms after intrahypothalamic application of streptozotocin
K Koltai, Z Keszthelyi, B Lukács, Z Karádi, T Past, G Mózsik · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Dokument
1161976
CareLit-ID
Jahr
2004
Publikation
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Zusammenfassung
Background: Streptozotocin (STZ) administered intraperitoneally is known to develop an animal model of type I diabetes mellitus. However, STZ injected directly into the ventromedial hypothalamic nucleus (VMH) induces various NIDDM-like feeding and metabolic alterations. Aim: We examined whether intrahypothalamic application of Cr(III) ions could diminish the adverse effects of centrally administered STZ in male Wistar rats. Methods: After stereotaxic surgery and a week-long recovery period, bilateral microinjection of 0.0037 M STZ (Ph 6.5–6.8) was carried out with and without chromium picolinate (2mg/ml, pH5) pr…
Schlagworte
Chromium
After
Diabetes Mellitus
Blood Glucose
Blood
Zeitschrift für Gastroenterologie
