Introducing the examination of macrolide resistant helicobacter pylory into the diagnostic practice and the first epidemiological data in the South-Alföld region

The aim of this study was to introduce the examination of macrolide resistant H. pylori into diagnostic practice, and to determine the resistant ratio in infected patients in Szeged and associated region. The target site of the macrolide antibiotics used in the eradication of H. pylori is the ribosome. However mutations in the sequence of ribosomal RNA can lead to resistance of the host organism. By the use of rRNA FISH, specific probes can reveal the three most frequent mutations. In the University Medical School of Szeged 476 examinations were carried out in patients in whom previously microscopical examinatio…