CareLit Fachartikel
Histone deacetylase Inhibitors have a profound proapoptotic activity in PNET cells
K Saravana Kumar, J Sonnemann, C Müller, JF Beck · Klinische Pädiatrie · 2004 · Heft 05
Dokument
1162123
CareLit-ID
Jahr
2004
Publikation
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DOI
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Zusammenfassung
Histone deacetylase inhibitors (HDACIs) are emerging as a new class of antineoplastic agents. Our purpose was to investigate the effects of the HDACIs suberoyl anilide bishydroxamine, trichostatin A, and sodium butyrate against PNET cell lines. Treatment with HDACIs resulted in the time- and dose-dependent accumulation of acetylated histone proteins. Concomitantly, HDACIs provoked the dissipation of the mitochondrial membrane potential, activation of caspase-9 and -3 and, consequently, apoptotic cell death. In addition, HDACIs were found to interact synergistically with irradiation or apoptosis-inducing cytokine…
Schlagworte
Antineoplastic Agents
Apoptosis
Caspase 9
Cytokines
Butyrate
Anilide
Work
Klinische Pädiatrie
