CareLit Fachartikel
Gender-Specific Expression of Liver Organic Anion Transporters and their Differential Regulation after DHEA Treatment in Rat
D Rost, K Kopplow, S Gehrke, S Mueller, A Stiehl, D Mayer, W Stremmel · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
1162285
CareLit-ID
Jahr
2004
Publikation
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Zusammenfassung
Background & Aims : Sex differences in drug pharmacokinetics have been well recognized and gender has been considered a risk factor for adverse events to medications yet the underlying mechanisms are incompletely understood. The aim of this study was to investigate the effect of gender and dehydroepiandrosterone (DHEA) treatment on the expression of hepatocellular transport proteins involved in uptake and secretion of organic anions in rat. Methods: Expression of the rat liver organic anion transporting polypeptides (Oatps) and multidrug resistance proteins (Mrps) was analyzed by RT-PCR, immunoblot analysis and…
Schlagworte
MDR
MRP
Multidrug Resistance
Ntcp
Oatp
gender
pharmakokinetics
After
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Zeitschrift für Gastroenterologie
