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SOCS–1 and SOCS–3 mRNA Expression in the Liver of Patients with Chronic Hepatitis C

HL Ly, G Ramadori, S Mihm · Zeitschrift für Gastroenterologie · 2004 · Heft 08

Dokument
1162288
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
HL Ly, G Ramadori, S Mihm
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-831769

Zusammenfassung

Interferon-± (IFN-±) is an important therapeutic cytokine with antiviral activities in acute and chronic hepatitis C virus (HCV) infection. It has also been shown to exert profound antireplicative effects in human hepatoma cell lines stably transfected with HCV replicons. In chronic HCV infection, however, only about half of the patients do respond to therapy in terms of a sustained virus eradication. Suppressor of cytokine signaling (SOCS) proteins constitute a family of eight proteins that interfere with signal transduction pathways. Two of them, SOCS–1 and SOCS–3, have been shown to inhibit activation of sign…

Schlagworte

hepatitis C virus (HCV) interferon-± (IFN-±) suppressor of cytokine signaling (SOCS) Hepatitis Cytokine Association Address Biopsy Zeitschrift für Gastroenterologie