Lamotrigine in Pediatric Epileptology: Long-Term Profile of Cognition and Vigilance in 120 Patients (the L-Child Project)

Purpose: The aim of this study was to determine the long-term profile of cognition and vigilance under lamotrigine (LTG) monotherapy and add-on therapy over a mean period of 2.5 years. Methods: Retrospective data were acquired through (i) structured interviews with epileptologists and (ii) structured parent interviews. Data on LTG dosage, co-medication, seizure frequency, EEG, effects, adverse effects, and epidemiological data were collected and stored in a database. Improvement or worsening of cognition and vigilance were rated on a 5-point scale 1) before any treatment with LTG; 2) during the dose-in phase; 3)…