Is there an Influence of Autonomic Nerves on Sensory Nerves in the Meninges? – Release of CGRP and PGE2 in vitro

The perivascular fibers in the dura mater are a putative source of headache. They are either efferent sympathetic or parasympathetic or afferent in the trigeminovascular system. Because the fibers join each other densely, one system might influence the other systems by neurotransmitter or peptide release. It is generally accepted that the trigeminovascular system is activated during headache, e.g., migraine. The release of the vasodilatory neuropeptide CGRP is an indicator for nociceptor activation and neurogenic inflammation which accompanies the headache. The release of PGE2 supports the inflammatory process.…